tert-butyl [(1S,2S)-2-hydroxycyclohexyl]carbamate

tert-butyl [(1S,2S)-2-hydroxycyclohexyl]carbamate - Names and Identifiers

Name	tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate
Synonyms	2S)-2-hydroxycyclohexyl]- 1S,S-Boc-2-aMinocyclohexanol (1S,2S)-trans-N-Boc-2-Aminocyclohexanol tert-butyl (1S,2S)-2-hydroxycyclohexylcarbamate tert-butyl [(1S,2S)-2-hydroxycyclohexyl]carbamate tert-butyl N-[(1S,2S)-2-hydroxycyclohexyl]carbamate tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate Carbamic acid, [(1S,2S)-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester CarbaMic acid, N-[(1S,2S)-2-hydroxycyclohexyl]-, 1,1-diMethylethyl ester Carbamic acid, [(1S,2S)-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester (9CI)
CAS	145166-06-9
InChI	InChI=1/C11H21NO3/c1-11(2,3)15-10(14)12-8-6-4-5-7-9(8)13/h8-9,13H,4-7H2,1-3H3,(H,12,14)/t8-,9-/m0/s1

tert-butyl [(1S,2S)-2-hydroxycyclohexyl]carbamate - Physico-chemical Properties

Molecular Formula	C11H21NO3
Molar Mass	215.29
Density	1.06±0.1 g/cm3(Predicted)
Boling Point	337.7±31.0 °C(Predicted)
Flash Point	158.044°C
Vapor Presure	0mmHg at 25°C
BRN	5810950
pKa	12.11±0.40(Predicted)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.485
Physical and Chemical Properties	Storage Conditions: 2-8 ℃

tert-butyl [(1S,2S)-2-hydroxycyclohexyl]carbamate - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R50 - Very Toxic to aquatic organisms
Safety Description	61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 3077 9/PG 3
WGK Germany	3

tert-butyl [(1S,2S)-2-hydroxycyclohexyl]carbamate - Introduction

tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate, also known as N-((2S,1S)-2-(1-methylethoxy) cyclohexyl) butyrate, it is a compound with the chemical formula C14H25NO3.

Nature:
tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate is a colorless to pale yellow liquid. It has a low boiling point and flash point, and can be dissolved in a variety of organic solvents.

Use:
tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate is commonly used as a reagent in organic synthesis. Because it contains Ester and amine functional groups, it can be used as an intermediate and catalyst in some chemical reactions. It is mainly used in the synthesis of drugs, pesticides and other organic compounds.

Method:
tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate can be obtained by reacting N-hydroxybutyramide with 2-bromocyclohexanol under alkaline conditions. The specific steps can be: first of all, the N-hydroxybutyramide and alkaline conditions of the alkali solution mixed, and then in the cooled solution drop 2-bromine cyclohexanol, after the reaction is completed by washing, steps such as neutralization and extraction give the target product.

Safety Information:
The use of tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate should pay attention to safe operation. It may be irritating to the eyes, skin and respiratory tract and may have health effects. Wear appropriate personal protective equipment to avoid contact with skin and eyes. At the same time, to understand and comply with the relevant safety operation precautions and treatment methods.

Last Update：2024-04-09 21:11:58